Friday, June 10, 2005
This Day:

Genes control the growth and development of our body. From the conception till death, the genes encode and regulate protein development, and also make sure that a eye grows in the eye socket and not a nose:)). There is considerable interest in the medical community about how the genes manage to make sure that the body develops as it does, since technically, all the cells in our body carry the same genetic material. It is the way the genes switch on and off that gives our body the final shape and form.

Fruit Fly compound eye, and its micrograph image (Courtesy: Wash. University)
One interesting find is how physics influences the growth of organs. For example, the laws of physics combine with the mutual attraction of two proteins to create the honeycomb pattern of fruit fly eyes, say molecular biologists at Washington University School of Medicine in St. Louis. This same combination of forces forms the delicate filtering structures of the mammalian kidney.
The findings are reported in the June issue of Developmental Cell, and provides a new understanding of how individual cells find their niche during organ developments. This means that the fruit fly eye can serve as a model for similar complex organs in higher animals.
Just as molecules of oil floating in water will gather together to exclude water molecules, cells with "sticky" molecules on their surface will gather together in clumps to exclude "non-sticky" cells during organ development. This property of cell adhesion has been previously proposed as a key to moving different cell types into the right positions as developing organs change from an immature, disorganized state to a mature, functional state.
Interestingly, the proteins that govern the growth of fruit fly eyes, are similar to those that contribute in the growth of mammalian kidneys! According to Professor Ross Cagan, The evolution of these similar proteins in two very distantly related groups of organisms and for these similar purposes suggests that the two systems, the developing kidney and the developing fly eye, used these proteins to solve the same problem—the problem of how to build intricate, fine-structured, tissues from a loose collection of cells:):).

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8 Comments:

At June 11, 2005 10:07 PM, Blogger Unknown said...
Wow! Now thats something!
 
At June 11, 2005 10:07 PM, Blogger Unknown said...
And yea! I'm back to the blogosphere
 
At June 11, 2005 10:40 PM, Blogger Sray said...
Welcome back! I was wondering what happened to you all of a sudden :).
 
At June 12, 2005 5:23 PM, Blogger Sray said...
Yes and no. This will help us understand how our kidneys and other complicated organs are easily formed from a very small set of genes. One fundamental aspect of physical laws is that systems tend to minimize the total energy as they evolve. So a droplet of water is always spherical, as that is the minimum energy structure. Once we understand how physical laws affect the growth of organs, we might be able to use them to grow artificial organs. Then we might be able to control aging as well, as aging might be the body trying to gracefully get rid of old cells, and thus minimizing the energy required to keep up the maintenance.
 
At June 14, 2005 9:13 PM, Blogger Unknown said...
Hmmmm..... So.... we are not entirely controlled by our genes..... that means, clones shouldnt be alike!
 
At June 14, 2005 10:30 PM, Blogger Sray said...
Clones are never alike :)). There are differences that accumulate when the brain develops, similar to why clones do not have same fingerprints!
 
At June 15, 2005 7:15 AM, Blogger Wayne Smallman said...
It's interesting to note that in a lot of instances, there's simply no background intelligence behind the design of things.

In this case, simple dumb mechanical principles are the mechanism...
 
At June 15, 2005 7:28 AM, Blogger Sray said...
Trial and error... thats the key in evolution...
 

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