Tuesday, April 26, 2005
This Day:

Humans need almost 8 hours of sleep per day. Some people enjoy sleeping (like me!), but when you think about it, sleeping for a third of your lifetime sounds like a awful waste of time :(. Now scientists at the University of Wisconsin have discovered a possible mutation in a single gene in the fruit-fly (Drosophila Melanogaster) genome, that allows the flies to get 30% less sleep than their normal counterparts!
The finding is important, as it might point to possible mutations in the human genome that might help us control sleep, and also shed light on human sleep needs. This fruit-fly gene has a counterpart in animal (and human) genome; so such a mutation might just be possible in humans too :).

Fruit Fly (Courtesy: University of Guelph)
Chiara Cirelli and colleagues discovered that flies with one particular gene variant, dubbed minisleep, needed only 3 or 4 hours’ rest per day, compared to 10 to 12 hours for a normal fly. The most interesting part: the flies, despite all the sleep deprivation, showed no sign of impairment.
They were also able to go without any sleep for much longer periods of time. The minisleep mutation is in a gene called Shaker, which codes for a protein that forms part of an ion channel in nerve cells. The same protein is found in mammals, and might serve the same function as in flies.
If we were able to conquer sleep, it might be helpful in a lot of ways. In particular, it will help those among us who always feel sleepy (including some of the readers here :D:D, you know who you are!), and also help people working odd or late hours, and of course the military might be really interested.

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21 Comments:

At April 28, 2005 1:11 AM, Blogger LEMNA said...
I couldnn comment you last night!It gave me error.Whyyy???
 
At April 28, 2005 4:05 AM, Blogger Sray said...
Blogger has problems sometimes.. due to server load and what-not :-).
 
At April 28, 2005 4:25 AM, Blogger Onkroes said...
"conquer sleep"

Hmmmmm. I understand some scientists believe sleep is a necessary 'reset device' the brain uses to sort thoughts out and re-assign pathways (from memory). If there was no sleep they theorise that people would actually go insane over time.

Have you heard of a "russian sleep" unit? I think it's just sci-fi at the moment (and every day more sci-fi things are becoming reality) but it's a device to 'force' REM sleep. If you combined the two advances that may work!
 
At April 28, 2005 4:39 AM, Blogger Sray said...
You might be right... a lot of things happen during sleep. For example, Research has found that studying for exams and then sleeping helps retain more for the long-term.

"Russian Sleep" machine thing is interesting :))... but I dont know if the two (the machine, and the minisleep mutation) can be combined.

By the way, there are mammals who sleep much much less than we do, and are still quite active. The question is: why do we sleep so much? Why did we evolve like this?
 
At April 28, 2005 6:49 AM, Blogger wise donkey said...
:)) that too from a fruit fly!!

i just find it so funny and at the same time so useful :D

whats the russian sleep machine? any link on it?
 
At April 28, 2005 6:57 AM, Blogger Sray said...
Fruit flies are a favorite for biologists, as a) they reproduce very rapidly b) their genes mutate quite fast c) Many common genes with us :).

Russian Sleep Machine: I am not sure it works... it might be partly a hype/legend. For more info, click here.
 
At April 28, 2005 1:30 PM, Blogger Sray said...
Yaa. me neither.. especially if it involves germ-line genomes. But it is nice to know what all can be done :-).
 
At April 28, 2005 3:19 PM, Blogger Sray said...
Me too :-). Even though I enjoy sleeping, it would be nice to control it when deadlines are near, and there is a lot of work to be done :-).

Well, perhaps I shouldnt keep postponing work till the last minute before deadlines :)).
 
At April 28, 2005 5:39 PM, Blogger Deb said...
My Dad is one of those rare individuals who needs very little sleep. That was the case when he was younger, at any rate. 4 hours per night was his comfortable routine.

I used to think I was unfortunate not to have inherited that trait. But now I think my subconscious world is equally valuable. Whatever my subconscience needs to work its magic is OK with me! I value my sleep time for more than just rest.

onkroes: Yes, sleep deprivation causes insanity. One of my kids was colicky, so I know!!
 
At April 28, 2005 5:43 PM, Blogger Sray said...
LOL!! Well, we all wish that from time to time, dont we? :-).
 
At April 28, 2005 7:08 PM, Blogger Sray said...
Oops, my previous comment was answer to "nothing like it"...

Deb, another interesting thing is: as people grow older, they need less and less sleep. But they are still quite active! Why cant that happen when we are younger? That is a mystery to me.
 
At April 29, 2005 2:00 AM, Blogger Akruti said...
Came here to tell u my exp today morning:),hope u dont laughout loudly,My mom was trying to wake me up at 8am in the morning and i was told her in a sleepy voice "what ma,u know yesterday i read in a blog,humans need eight hour sleep,i am trying to follow it" And pat came the answer "whoever it is,they must be talking abt humans,u dont come into the category,wakeup right now or i will put a bucket water on u:(((( " Well,i was refering to ur blog,have a greatday:)
 
At April 29, 2005 6:06 AM, Blogger Sray said...
:)):)).... as you can see from my picture, I am not a human either :D:D... so the research applies to neither of us :D:D.

Good one :)):)).
 
At April 29, 2005 9:24 AM, Blogger Wayne Smallman said...
"Hmmmmm. I understand some scientists believe sleep is a necessary 'reset device' the brain uses to sort thoughts out and re-assign pathways (from memory)."

Yes.

Your short-term memory is moved into long-term memory during sleep.

Your dreams are essentially a visual representation of your brain filing your thoughts and experiences.

Lack of sleep is one of the reasons why people hallucinate; their brains are trying to do an emerging back-up!

As I understand it, the brain needs a chemical called Seratonin [among others], but it's only produced during sleep when much of the brain is switched off or in low power mode.

This chemical is needed for muscle functions, that's why you ache when you're tired.

This is where Sray either corrects or fills out the details...

I remember watching a television program about narcolepsy, now that is weird. Just nodding off without warning.

It seems that the default state of the brain is at rest. Being awake requires effort. So with the average narcoleptic, the power switch is faulty and keeps breaking and going back to 'off' when it should be 'on'.

Not good!
 
At April 29, 2005 2:53 PM, Blogger Sray said...
Wayne: You are exactly right. When we sleep, our brain reorganizes whatever we learnt and experienced that day. It also makes the brain 'absorb' the experiences into your personality, for example, if you learnt swimming on that day, you will find that after waking up, you are swimming with less conscious effort.

Abt. serotonin. It is one of the major neuro-transmitters in the brain. Decreased levels of serotonin can cause body ache, and depression. Serotonin is given as an antidote for depression, and is also one reason why we go to sleep when on anti-depressants. Conversely, without serotonin, our thinking abilities are often impaired.

Gindy: I am sure experiments have been done with soldiers. It is not hard to stay awake. The problem is: people become zombies, and you dont want zombie soldiers! What the mutation might do is allow you to be alert, and aware of what is going on around you.

But one side-effect for the fruit-flies, that I just found out in a BBC article, was that the mutated flies (with less sleep) died earlier than others :-(:-(.
 
At April 29, 2005 11:48 PM, Blogger LEMNA said...
:DSo that is meeeee:D:D:D who was that reader whom needs sleep?!:D Emmm,so send me the gene then I can stay awake durin' the night:D 'n never feel sleepy in the company:D Emmmm, I need about 100 years of sleep:D
 
At April 30, 2005 12:38 AM, Blogger Sray said...
It will be nice, pal... but this gene also reduces one's life-span :-(. So, right now, it is not of much use, is it?
 
At April 30, 2005 4:44 AM, Blogger LEMNA said...
Nevermind about the life-span:)No use now:D
 
At May 01, 2005 5:18 AM, Blogger Wayne Smallman said...
"By the way, it reminds me of an X-Files episode (I don't know if you watch it)"

Yes, I saw that one.

The soldier was non other than B-movie star Tony Todd...
 
At May 06, 2005 5:19 PM, Blogger Sray said...
:)):))... yes, I have read it. I would recommend the book The Naked Ape by Desmond Morris. A must-read for all Kansasians ;-);-).
 
At May 21, 2007 1:01 PM, Anonymous Anonymous said...
Ah, that's grat. Hopefully they'll soon find a way to modify the human DNA in such way. So that we can work longer (fore the same money) for better profits of the corporations.
 

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