Saturday, June 11, 2005
This Day:

The fundamental carrier of life on Earth is a Cell. Cells are the structural and functional unit of all living organisms. The organisms range from single celled bacteria, to trillions of cells in large animals such as whales (humans consist of about 50 trillion cells, give or take a few billion ;)). Therefore, any new technique that enables us to understand how individual cells behave, or how they interact with their neighbors or the surroundings, has a lot of practical applications.
Now scientists at the University of Chicago and Argonne National Laboratory have constructed a computer simulation that allows them to study the relationship between biochemical fluctuations within a single cell and the cell's behavior as it interacts with other cells and its environment.

Simulation (Courtesy: University of Chicago)
The simulation is called AgentCell. It is a model based on agents, which are semi-autonomous program modules that interact with other agents. For example, in a bacterial study, there will be hundreds of bacteria modeled, with each having it own chemotaxis network (phenomenon in which cells direct their movements according to certain chemicals in their environment), motors and flagella. If the cell behavior could be accurately modeled at the chemical level, then the aggregate network can be used to simulate large collections of cells, including bacterial swamps, diseases, and even population growths. Not surprisingly, this technique has possible applications in cancer research, drug development and combating bioterrorism.
A major goal in single-cell biology today is to document the connection between internal biochemical fluctuations and cellular behavior. AgentCell should be able to help in this research. It has already simulated some actual bacterial behavior: for example, In the bacteria E. Coli, one type of protein controlled the sensitivity of its chemotaxis system, which helps the bacteria find food. In the simulation, when the level of that protein was changed, it would change the sensitivity of the cell. The actual real-life cell behaved exactly in the same way:):).
The end goal of this research is focussed on solving problems involving bio-terrorism and disease spread. But another interesting by-product could be understanding how macro-processes (such as life) evolve from micro-processes (such as chemistry and fluid/energy transport systems):):).

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6 Comments:

At June 13, 2005 7:16 PM, Blogger Sray said...
Hmmm... it is possible! But the goal of this project is to simulate small sets of cells to start with. Perhaps then will treat a clump of cells as a single unit (at least at the first approximation), and proceed from there.
 
At June 14, 2005 9:08 PM, Blogger Unknown said...
Hmmmm. Now I wonder what is life! If life is just a lump of chemicals reacting in a particular sequence.... these digital bacteria, that behave according to sequences of electronic signals.... are also living!
 
At June 14, 2005 10:29 PM, Blogger Sray said...
I am inclined to say that anything that can be simulated programmatically (hence is deterministic) is not life. After all, if it is deterministic, then it is nothing but an automaton.
 
At June 17, 2005 9:44 PM, Blogger Unknown said...
That's an interesting view.... A world similar to ours should be uncertain(in the quantum mechanical sense).
 
At June 20, 2005 6:55 AM, Blogger Sray said...
But non-determinism can arise from deterministic components, e.g. weather, turbulence etc.. so perhaps it is not that impossible after all!
 
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