Blogger
Get your own blogNext blog
BlogThis!'); langTitle(); document.write(''); /*for(var n=0; n<10; n++) document.write(' ');*/
KL

Scientific Thoughts

The eternal mystery of the world is its comprehensibility - Albert Einstein

Sunday, July 31, 2005

Once it was in the realm of science-fiction. Yes, DNA sequencing (and its associated field, called Bioinformatics) has come a long way:). The first attempt at sequencing begun in 1990, and it took nearly 14 years to complete. Now scientists are getting much better at it, and faster and more accurate genome deciphering techniques are on the horizon. A report published online by the journal Nature describes one such method that is 100 times faster than conventional ones:):).

Microscopic Image of human chromosomes (Courtesy: BBC)
The new technique has been developed by Jonathan M. Rothberg of 454 Life Sciences Corp. in Branford, Connecticut and his colleagues. The technique uses tiny fiber-optic vessels (55 microns x 50 microns) to detect and sequence hundreds of thousands of DNA molecules simultaneously. The results indicate that the setup can sequence 25 million base-pairs (each human chromosome is about 51 to 245 million base-pairs long, and we have 46 chromosomes) in a single four-hour run with greater than 99% accuracy:):).
A single such run of the system was able to sequence entire genome of the parasitic bacterium Mycoplasma genitalium (one of the organisms with the smallest genome), which includes 580,069 base-pairs!! And with an accuracy of 99.96%, that is just plain astounding:).

Faster DNA Sequencing

7/31/2005   5 comments Post a Comment

5 Comments:

At August 02, 2005 1:29 PM, Blogger Saravana said...
Hmm better science, better medicines, better life.
 
At August 02, 2005 4:07 PM, Blogger Sray said...
You are right, Lunatic, that the classical techniques of comparing anatomical similarities is obsolete. Recently, there have been cases where accepted taxonomic structures have been rewritten after the genetic codes were compared.

When comparing DNA sequences, scientists look for similarities in regions that do not change much across generations or different members of the species. Such regions contain critical genes essential for the growth and survival of the organisms. Our genomes mutate (on average) at a constant rate, so from the number of differences between such portions of genomes between different species, we can determine how far back in time the two species diverged! Then we know the phylogeny of the organism :):).

Saravana: Very true :).
 
At August 03, 2005 5:10 AM, Blogger Sray said...
Yaa, in a way. Interesting pieces of genomes from two different species can be compared to see how many base-pairs are different (among other things), and that gives an estimate of the "distance" between the two species.
 
At August 04, 2005 3:39 AM, Blogger Sray said...
Thanks, Atheist, I misspoke there. But I am sure comparing errors in existing genes also helps; for example, recently it was discovered that cats have a flawed gene that renders them incapable of tasting sweet flavor.. so one can therefore see where their position in the animal tree would be.

Creationists wont believe even if there were a god and he/she were to come down and tell them that evolution did happen ;).
 
At August 05, 2005 6:30 AM, Blogger Sray said...
You should ask the logically-minded creationists (dunno if it is a oxymoron) to consider this for a moment. Suppose they had never read the Bible, or heard of creationism. Then, given all these evidences about evolution, would they be inclined to believe in it? If yes, then do they see any stronger evidence in the Bible that refutes it?

I wonder how they would answer. Then again, a logically-minded creationist might be rarer than the white elephant.
 

Post a Comment

About Me

My Photo
Name: Sray
From: India/USA
Mood: 
Free Guestmap from Bravenet.com

Its only words, and words are all I have, to take your heart away...

View my complete profile

Favorite Music

Previous Posts

  • Earliest Dino Embryos
  • NanoTube Circuits
  • Tenth Planet!!
  • Instant Evolution
  • Probing Earth
  • PetaFlops!
  • Evolution And Butterflies
  • Earthquake Rumbles
  • Windows Vista
  • Stone Age In Borneo

Profiles/Feeds/Visitors

Technorati Profile
Technorati Search
Technorati Ping
BlogShares

Atom Feed
RSS Feed
 
I am...

Click My Pet Cloudy!

adopt your own virtual pet!

Her friends
Lettuce   Rainy   Hammy

    Frequently Read

      Blogroll Me!

Latest Science News