Friday, June 17, 2005
This Day:

Each of our brains are unique. In addition to genetic factors, conditions inside the womb as well as random factors contribute a lot to the way our brains are, and the way we are. No two brains are alike; even the brains of identical twins are considerably different. An interesting find now suggests that there is a connection between the variety in the brain’s neurons and certain genes that can change their position in the genetic code. These so-called jumping genes (or Transposons) may gently scramble the blueprints for the brain. According to Fred Gage from the Salk Institute, this mobility adds an element of variety and flexibility to neurons in a real Darwinian sense of randomness and selection.

Jumping Genes (Courtesy: Saint Anselm College)
Transposons have been known for a long time. These are genes that can move around to different positions within the genome of a single cell. This can cause mutations and change the amount of DNA in the genome. This can disrupt the functions of neighboring genes, and thus can directly change some trait in the species, which if beneficial, might aid in its evolution. Jumping genes are found in all living things. Approximately 20 percent of the genetic code in mammals is of the jumping variety! But only a small fraction of these are active – which means they are able to successfully reinsert themselves into a new spot in the code.
The fact that these certain jumping genes can directly affect the brain is what is interesting in Dr. Gage's research, to be published in the journal Nature. He found that a gene called long interspersed nuclear element-1, or L1 for short, jumped positions in cultured brain cells of rats. This is the first time such a jump has been seen in cells other than the sperm or the egg:).
Evolutionarily, this has significant implications. It might be that we owe our intelligence to some so-called jumping gene, and not to a gradual adaptation and improvement as the human species evolved:).

(Hide) (Show)

9 Comments:

At June 17, 2005 7:22 AM, Blogger Wayne Smallman said...
"Evolutionarily, this has significant implications. It might be that we owe our intelligence to some so-called jumping gene,..."

Presumably, that would punctuated equilibria?

If this is the mechanics of evolution, then it's curious just how much more change and variety go into the brain.

I would have imagined that the brain was much less able to deal with such variation...
 
At June 17, 2005 2:01 PM, Blogger Sray said...
I thought so too. But I think this sort of thing is pretty rare.. and noting that there are so many congenital brain-defects these days, I wonder if at least some of those are not due to jumping genes.

Once in a while a jumping gene might be useful, and it will take the evolution into a new path.
 
At June 17, 2005 3:39 PM, Blogger Wayne Smallman said...
There are even more factors these days, such as environmental chemicals, diet and so on.

It's as if nature knows that the brain is the engine and is striving to create something amazing, even if at the expense of the good health of individual.

Look at this way, such failures exit from the gene pool by virtue of not being suitable breeding material...
 
At June 17, 2005 10:08 PM, Blogger Unknown said...
So..... my genetic makeup is constantly changing?!?!?! And that too of the brain! Whoa! That means I can go conk any minute!
 
At June 20, 2005 6:42 AM, Blogger Sray said...
Wayne: Nature always does that. For evolution, a few individuals here and there are expendable. Also, since such individual deviations do not threaten the survival of species, the possibility of such deviations stay in our gene pool.
 
At June 20, 2005 6:43 AM, Blogger Sray said...
Vijay: Hmmm.. but they can be a reality for other reasons too.. nothing to do with jumping genes, I think!
 
At June 20, 2005 6:45 AM, Blogger Sray said...
Sudhir: We are composed of trillions of cells. The genetic code in individual cells are always mutating, and if the cells behave oddly (like in cancer) due to that change, there are systems in our body that normally would force that cell to commit suicide. Unless the mutation is in your germ line (sperm or egg), the mutation is not passed on!
 
At June 20, 2005 7:48 AM, Blogger Wayne Smallman said...
I've just read an article on possible evidence to support the idea of Punctuated Equilibrium.

So now the idea in the minds of some is that gradual change isn't the normal mechanism, sudden burst is.

Question is: why?

Given that there's typically a pong period between each burst, could this period be related to relative population size for each species?

So that after several tens of millions of years, a burst occurs to stir up the gene pool...
 
At June 20, 2005 8:27 AM, Blogger Sray said...
Yaa.. I read it too. And this is not a new theory. Whenever there is a need for evolution (that is, when the population is below a threshold level or is isolated), a sudden mutation/evolution in one individual rapidly passes on to a lot of children in the next generation. So such bursts are more likely to happen when the population consists of fewer individuals.
 

Post a Comment